MILNER: EVENTS CALENDAR
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Webinar: Harnessing the power of whole genome arrayed screening to discover new mechanisms and targets in rare genetic conditions
9 October|10:00 am - 11:00 am
🗓️ 9th October
⏰ 10:00am
📍 Online (Zoom)
Join us for this webinar presented by the MRC-AstraZeneca-University of Cambridge Joint Functional Genomics Screening Laboratory.
Speaker: Dr Delphine Larrieu, Altos Labs
Abstract: Progeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. They are caused by mutations in nuclear envelope proteins, who play major roles in maintaining the structure of the nucleus, as well as the organisation of the chromatin. As a result of these mutations, patient-derived cells display a dramatic loss of nuclear envelope integrity, characterised by nuclear shape distortion, nuclear envelope ruptures and abnormal localisation of nuclear envelope proteins. With the goal of identifying new players that could restore nuclear envelope integrity and cell health in Progeria patient cells, we designed a whole genome screen, looking for genes that could reverse multiple nuclear envelope associated phenotypes at once. These phenotypes can only be assessed by microscopy on adherent cells, preventing the use of pooled, flow cytometry-based screening strategies. We therefore implemented a whole genome, CRISPR arrayed screen that proved to be a powerful approach for identifying new genes enhancing cellular resilience in premature aging and uncover novel biology behind progeria-associated cellular dysfunction.